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Many studies over the years have shown evidence of an association between herpesviruses and dementia, suggesting at least some influence on susceptibility or progression, if not frank causation. Interestingly, presence of herpes simplex virus type 1 (HSV-1) and another member of the Herpesviridae family, varicella zoster virus (VZV) have been associated with amyloid plaques in the central nervous system and recent evidence shows that amyloid plaques and tao-neurofibrillary tangles, hallmarks of Alzheimer’s pathology, are actually antimicrobial peptides produced by host defense mechanisms. A recent very large case-control study of people with Alzheimer’s showed a highly significant increased history of infection with HSV-1, and HSV-2, or VZV. [Liu, Y, et al. Association between herpes simplex virus type 1 and the risk of Alzheimer’s disease: a retrospective case-control study. BMJ Open 2025;15:e093946. Doi:10.1136/bmjopen-2024-093946] Is this case-control study showing greater prevalence of Alzheimer’s in people with a history of herpesvirus infection actually reflecting causation of the dementia by the virus?
ClosedNicola asked 2 weeks ago • 
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Dr. Alan Inglis, in his March, 2026 Newsletter, Nutrition and Health, had an article titled: “Alzheimer’s Disease: The Viral Trigger We’ve Been IGNORING.” It describes research on the association of Alzheimer’s disease and Herpes Simplex Virus Type 1 (HSV-1). Is this, indeed, at least one viral cause of dementia cases, including Alzheimer’s? What can Creator tell us?
ClosedNicola asked 3 weeks ago • 
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Dr. Inglis points out that HSV-1 is more likely to enter the brain in those who carry the APOE gene. Is having that gene a predisposing factor to viral pathogenesis of Alzheimer’s?
ClosedNicola asked 3 weeks ago • 
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Dr. Inglis describes using Cat’s Claw liposomal extract as a possible preventive measure for Alzheimer’s as the inner bark of this plant species, Uncaria tomentosa, has confirmed antiviral and anti-inflammatory activity. He said that a clinical study of a Cat’s Claw cream performed as well as an antiviral cream containing acyclovir for topical treatment of HSV-1 cold sores. Would an oral Cat’s Claw supplement be an effective preventive measure for Alzheimer’s?
ClosedNicola asked 3 weeks ago • 
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