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A viewer asks: “Being aware of Creator’s previous answers on Vitamin D3 supplementation I was shocked to discover a paper from 2014 “A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D”. The paper claims that the Recommended Daily Allowance advocated by the Institute of Medicine for Vitamin D was incorrectly calculated! In fact, analyzing the data correctly, nearly 9000 IUs per day are required to achieve target levels (600 IU per day is the USA recommended level). I was struck by how closely the 9000 IU figure matched Creator’s “daily doses of 5,000 to 10,000 IU vitamin D3 will rarely be harmful.” What is Creator’s perspective on this “miscalculation” coming to light?”
ClosedNicola asked 1 week ago • 
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A British group reported recently that administration of vitamin D2, which is converted to vitamin D3 by the body, may be disadvantageous. A review of random controlled trials showed that taking vitamin D2 can lead to a decrease in vitamin D3 levels, the more active form generated by sunlight exposure. The research indicates that D2 supplementation may not only be less effective, but can also lead to lower concentrations of D3 in the circulation. [Emily I G Brown, et al. Effect of Vitamin D2 Supplementation on 25-Hydroxyvitamin D3 Status: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutr Rev, 2025 Sep 18:nuaf166.doi: 10.1093/nutrit/nuaf166]. Is this an accurate and meaningful assessment? What is most important for us to know?
ClosedNicola asked 1 week ago • 
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To help probe the issue of viral involvement in cancer, a study was reported in 2018 of a library of gene sequence data on file for a repository of normal and malignant human tissue samples from 3,052 participants across 22 different cancer types. Results showed that five viral families are prevalent in human cancer. These include the Papillomaviridae, Polyomoviridae, Hepadnaviridae, Flaviviridae, and Herpesviridae. Viruses were detected in 7.5 – 98.8% of patients of seven cancers: bladder carcinoma, cervical squamous cell carcinoma, colon adenocarcinoma, head and neck squamous cell carcinoma, liver hepatocellular carcinoma, rectum adenocarcinoma, and stomach adenocarcinoma. [Cantalupo PG, Katz JP, Pipas JM. Viral sequences in human cancer. Virology. 2018 Jan 1;513:208-216.] Having found that viral sequences were present in most of the files they analyzed from human tumor databases, the authors pointed out there are two possible explanations: first, a given virus may be present in human tissue because it infects humans, perhaps even contributing to tumorigenesis; and second, the viral detection may be due to an artifact. This seems to ignore additional uncertainties. Such studies showing evidence of a viral presence assume it to be an aggravating factor, a “driver” of malignancy and not necessarily a cause. However, if a low-level, smoldering, virus causes malignant transformation, once that is triggered, it need not continue growing in order for tumors to form and spread, so a low number of virus particles might end up being deadly but disregarded as having an important role if only present in low numbers or below level of detection. Also, there is the limitation that only known viral sequences were searched for, so no novel viruses could even be discovered by this survey. What is Creator’s perspective?
ClosedNicola asked 1 week ago • 
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A review article shows little or no benefit of supplementing patients with vitamin D3 for bone fractures (T. Gatt, A. Grech, and H. Arshad. The effect of Vitamin D supplementation for bone healing in fracture patients: a systematic review. Adv. Orthopedics Volume 2023, Article ID 6236045). However, the supplement doses of vitamin D3 were either low, 800-2000 IU daily, or quite high loading doses orally or systemically of 100,000 to 300,000 IU. Was their negative assessment justified or were the studies flawed? Would taking a 5000 to 10,000 IU dose of vitamin D3 daily, give significant benefit for healing bone fractures?
ClosedNicola asked 2 months ago • 
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A systematic review of 416 medical journal articles affirmed a strong association between higher serum vitamin D levels and a lower risk of bladder, breast, colon, endometrial, esophageal, gallbladder, kidney, ovarian, pancreatic, rectal, stomach, and vulvar cancers, as well as Hodgkin’s and non-Hodgkin’s lymphomas. The review also uncovered lower risks of metastasis and mortality from cancer in patients with higher levels of vitamin D. While vitamin D levels of 20 ng/ml (50 nmol/L) were adequate for bone and muscle health, reduction of cancer risk and mortality required levels greater than 40 ng/ml (100 nmol/L) and fell further with levels above 50 ng/ml (125 nmol/L). The review cautioned that studies showing no benefit for those taking less than 5,000 IU per day might be misleading. [Wimalawansa SJ. Vitamin D’s impact on cancer incidence and mortality: a systematic review. Nutrients. 2025 Jul 16;17(14):2333. Doi: 10.3390/nu17142333.] Is this a fair summary of vitamin D benefits for limiting incidence and severity of cancer?
ClosedNicola asked 2 months ago • 
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You have told us that 5000 IU of vitamin D3 taken twice a day would be safe and helpful for many, many people. Is that enough to get serum levels in a useful range for cancer prevention?
ClosedNicola asked 2 months ago • 
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Studies have shown that vitamin D levels have an inverted U-shaped curve, where low levels (<29.7 nmol/L) result in shortened telomeres on DNA, a sign of aging, but so do high levels of vitamin D (>95.9 nmol/L). Population-based studies and randomized clinical trials have shown a U- or J-shaped curve and suggested an increased risk of adverse outcomes in those with the highest serum Vitamin D levels, including falls, fractures, and frailty. Most studies have reported a higher risk in those participants with serum levels above 100 nmol/L. Are the deleterious effects noted in these studies caused by elevated vitamin D? If so, your support for taking 5,000 to 10,000 IU of vitamin D3 daily seems risky. What is most important for us to know?
ClosedNicola asked 2 months ago • 
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How effective is the Primal Force supplement, Telo X Nano, for adding to longevity?
ClosedNicola asked 2 months ago • 
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A viewer asks: “Would I benefit from taking Telo X Nano? I am taking nearly all the ingredients except for arginine alpha ketoglutarate and carnosine, although not in the “nano” form promoted by Primal Force as achieving better bioavailability.”
ClosedNicola asked 2 months ago • 
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A recent paper describes a pretty convincing case study of a skin cancer caused by Human Papillomavirus. Was this accurately described?
ClosedNicola asked 4 months ago • 
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You have told us that 85% of cancers are caused by viruses, and also that, contrary to dermatologists’ thinking, malignancies in the skin, including melanoma, are not due to sun exposure as much as it is to electromagnetic frequencies, which bombard people’s skin. What percent of skin carcinomas are caused by viruses?
ClosedNicola asked 4 months ago • 
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Arguably, the biggest champion over the years for cancer as a metabolic disease and largely ignored by medical opinion leaders, has been Dr. Thomas Seyfried who has promoted ketogenic diets as an adjunct to conventional treatment. A state of ketosis lowers blood sugar which tumor cells need, and elevates ketone bodies which normal cells can use for energy but tumor cells can’t. But even he seems blind to the clues about viral causation. In a 2014 study in Cancer Letters, he augments his theory of the central role of metabolism in glioblastoma in describing how 90% of brain tumor cells are infected by cytomegalovirus, “which is a supercharger for allowing tumor cells to use glucose and glutamine.” That biochemical pathway allows energy for tumors to grow despite inadequate oxygenation. But he doesn’t ask, why are viruses there to begin with and what other role might they play? Is this an example of mind control suppression to limit scientific progress?
ClosedNicola asked 4 months ago • 
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What percent of Secondary Sarcopenia cases associated with systemic diseases like cancer and organ failure are caused by chronic viral infection?
ClosedNicola asked 5 months ago • 
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Does the Antiviral Regimen have meaningful activity against malignant cells or tumor formation so that it would be an effective treatment, alone or in combination with other substances?
ClosedNicola asked 5 months ago • 
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Does Cannabitol 5000 have meaningful activity against malignant cells or tumor formation so that it would be an effective treatment, alone or in combination with other substances?
ClosedNicola asked 5 months ago • 
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