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A recent study showed that nine pharmaceuticals commonly used in residential aged care significantly enhanced bacterial resistance to antibiotics, adding to the growing worldwide problem of declining antibiotic effectiveness, and the attendant morbidity and mortality. These included Advil, Tylenol, diclofenac (an anti-inflammatory to treat arthritis), furosemide (for high blood pressure), metformin (for high sugar levels linked to diabetes), atorvastatin (to help lower cholesterol and fats in the blood), tramadol (a stronger pain medication post-surgery), temazepam (used to treat sleeping problems), and pseudoephedrine (a decongestant). Are these or other drugs also causing lowered immune defenses against chronic viruses, which you have confirmed are the cause of 85% of chronic diseases? Hanbiao Chen, Sylvia A. Sapula, John Turnidge, Henrietta Venter. The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli. npj Antimicrobials and Resistance, 2025; 3 (1) DOI: 10.1038/s44259-025-00144-w.
ClosedNicola asked 2 months ago • 
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Was the research, including the clinical data, for the paper we asked you about, “Acute inflammatory response via neutrophil activation protects against development of chronic pain,” valid and not corrupted by the interlopers to malign seemingly useful common painkillers? Given your warnings that clinical research cannot always be trusted, we just want to be sure. What is most important for us to know?
ClosedNicola asked 2 months ago • 
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The phenomena seem quite striking which are reported in the paper, “Acute inflammatory response via neutrophil activation protects against development of chronic pain,” by Marc Parisien et al. Sci Transl Med. 2022 May 11; 14(644). These authors showed in animal models that painkillers like corticosteroids and NSAIDs, but not analgesics like morphine or lidocaine which lack anti-inflammatory effects, end up prolonging pain, because without neutrophil activation being allowed to happen as part of an immune response, acute pain may become chronic. A clinical study confirmed that among patients whose lower back pain had become chronic, it was exclusively those who had been treated with NSAIDS who went on to develop neuropathy. Was this a valid study with broad implications about the unexpected downside of anti-inflammatory medication for moderating pain? What is Creator’s perspective?
ClosedNicola asked 2 months ago • 
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I shudder when I consider I spent years striving to develop inhibitors of neutrophil activation as therapeutics for autoimmune disease. Was that not only misguided, but a sinister consequence of interloper manipulation to encourage the field of immunopharmacology, knowing it could make things worse? What can Creator tell us about the medical implications for using anti-inflammatories?
ClosedNicola asked 2 months ago • 
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