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The phenomena seem quite striking which are reported in the paper, “Acute inflammatory response via neutrophil activation protects against development of chronic pain,” by Marc Parisien et al. Sci Transl Med. 2022 May 11; 14(644). These authors showed in animal models that painkillers like corticosteroids and NSAIDs, but not analgesics like morphine or lidocaine which lack anti-inflammatory effects, end up prolonging pain, because without neutrophil activation being allowed to happen as part of an immune response, acute pain may become chronic. A clinical study confirmed that among patients whose lower back pain had become chronic, it was exclusively those who had been treated with NSAIDS who went on to develop neuropathy. Was this a valid study with broad implications about the unexpected downside of anti-inflammatory medication for moderating pain? What is Creator’s perspective?
ClosedNicola asked 6 months ago • 
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I shudder when I consider I spent years striving to develop inhibitors of neutrophil activation as therapeutics for autoimmune disease. Was that not only misguided, but a sinister consequence of interloper manipulation to encourage the field of immunopharmacology, knowing it could make things worse? What can Creator tell us about the medical implications for using anti-inflammatories?
ClosedNicola asked 6 months ago • 
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Acetaminophen (paracetamol) also marketed as Tylenol, is one of the most widely-used drugs by pregnant women and children and studies have mounted showing a link between prenatal or early childhood exposure and neurodevelopmental disorders, like autism, attention-deficit hyperactivity disorder (ADHD), language delays, behavioral problems, and lower IQ. Are those studies accurate and valid, or has there been interloper interference to create another cover story to mask their deliberate toxic manipulations of the brains of infants?
ClosedNicola asked 6 months ago • 
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A number of research studies have been called into question because of poor reproducibility when an attempt to replicate their findings failed. A “replication crisis” has been noted for psychology, sociology, education, economics, and medical research. For example, a detailed inquiry was mounted to replicate 193 experiments from 53 top cancer papers published from 2010-2012. Only a quarter of the original findings were able to be reproduced. Moreover, even for effects that were reproduced, the magnitude averaged 85% less than observed in the original investigations. This is concerning because such experiments are crucial for deciding what to pursue for drug development and when to proceed to clinical trials. Unreliable results not only waste money but expose patients to unnecessary risks. While there are many understandable reasons why results can vary, what can Creator tell us about hidden reasons for such poor reproducibility and their impact on the reliability of scientific inquiry?
ClosedNicola asked 8 months ago • 
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Is Chaga an effective antiviral? If so, how can we rank the relative benefit of Chaga vs. Anamu and Galangal if cost is a limiting factor?
ClosedNicola asked 2 years ago • 
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The MitoQ supplement is promoted as containing a particular form of Co-enzyme Q10 which is well-absorbed by mitochondria, unlike ordinary Co-Q10. Is it critical that people take this special form, or is that more a handy marketing tactic?
ClosedNicola asked 11 months ago • 
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Is it actually the case that ordinary Co-Q10 in supplements is transformed intracellularly into a form that can be taken up by mitochondria readily? This would seem to be an almost necessary regulatory mechanism to adjust the levels of bioactive Co-Q10, given that certain diets might contain excessive Co-Q10.
ClosedNicola asked 11 months ago • 
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A viewer asks: “I loved the last Divine Life Support webinar and see how important the Mitochondrial aspect is. Since you’ve already compared various products, could you please ask Creator how does L’Evate You compare and rank to those in Creator’s list?”
ClosedNicola asked 1 year ago • 
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A preprint from a Cleveland Clinic study just reported, claimed not only that this year’s trivalent flu vaccine failed to show a protective effect, but those vaccinated had a 27%, significantly increased, likelihood of becoming ill. Was this the true outcome and reported accurately, or was the study flawed? What is most important for us to know?
ClosedNicola asked 1 year ago • 
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A viewer asks: “Another practitioner and I are trying to find an alternative to the Microingredients.com to be purchased from the UK. We have a few brand names and would be most grateful if Creator might suggest the better alternative brand to choose from without being leading, of course: Antioxi, Real Mushrooms, Time Health, Kiki Health, Bristol Fungarium, British Vitamins, Oriveda, Forest Whole Foods, and Go Superfoods. There are so many more to choose from but with a variety of clarity around chaga, its extraction process, content, and third-party verification, we are therefore asking for your help after spending much time on this.” The chaga supplement from oriveda.com offers 900 mg per serving, which is 30% beta-glucans, 3.9%polyphenols, 3.4% triterpenes, and 2.3% betulinic acid. How would you rank its effectiveness compared to the chaga from Time Health or Kiki Health?
ClosedNicola asked 1 year ago • 
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Would the best of these UK suppliers of chaga be equal or superior to Antioxi chaga, said to contain 40% beta-glucans? How would the best of these compare to our recommended Microingredients chaga available in the US?
ClosedNicola asked 1 year ago • 
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Is the beta-glucan content an important criterion for comparing potential efficacy of commercial chaga supplements? Does the fact it was measurable in the product asked about also indicate that because beta-glucans were released during extraction, they will likely be bioavailable?
ClosedNicola asked 1 year ago • 
225 views0 answers0 votes
Zebora has made two new versions of a supplement I am taking which now, have 400 mg of CoQ10 instead of 300 mg and 20 mg of PQQ (pyrroloquinoline quinone) instead of 10 mg. One of them matches the older version in also containing 60 mg of Omega 3s, 30 mg of Sunflower lecithin, and 10 mg Black Pepper extract. The other new version lacks the Omega 3s and Sunflower lecithin, but has 24 mg of Vitamin E and 100 mg of Trans-Resveratrol plus 5 mg of Black Pepper Extract. Which of these supplements is the best to recommend as part of a compilation to make a more economical version of the Advanced Mitochondrial Formulation?
ClosedNicola asked 1 year ago • 
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A viewer asks: “I found information on lumbrokinase that cleans arteries. Karl, can you ask Creator if it is a good addition to the present ones I’m using? Also, if any other supplements to clean plaque in arteries would help?” What can we tell him?
ClosedNicola asked 1 year ago • 
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How safe and effective is the supplement Venoplus 8 from Simple Promise for reducing arterial plaque and expanding blood vessel diameter? How does it compare to lumbrokinase in benefits?
ClosedNicola asked 1 year ago • 
301 views0 answers0 votes
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