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A systematic review of 416 medical journal articles affirmed a strong association between higher serum vitamin D levels and a lower risk of bladder, breast, colon, endometrial, esophageal, gallbladder, kidney, ovarian, pancreatic, rectal, stomach, and vulvar cancers, as well as Hodgkin’s and non-Hodgkin’s lymphomas. The review also uncovered lower risks of metastasis and mortality from cancer in patients with higher levels of vitamin D. While vitamin D levels of 20 ng/ml (50 nmol/L) were adequate for bone and muscle health, reduction of cancer risk and mortality required levels greater than 40 ng/ml (100 nmol/L) and fell further with levels above 50 ng/ml (125 nmol/L). The review cautioned that studies showing no benefit for those taking less than 5,000 IU per day might be misleading. [Wimalawansa SJ. Vitamin D’s impact on cancer incidence and mortality: a systematic review. Nutrients. 2025 Jul 16;17(14):2333. Doi: 10.3390/nu17142333.] Is this a fair summary of vitamin D benefits for limiting incidence and severity of cancer?
ClosedNicola asked 7 hours ago • 
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You have told us that 5000 IU of vitamin D3 taken twice a day would be safe and helpful for many, many people. Is that enough to get serum levels in a useful range for cancer prevention?
ClosedNicola asked 8 hours ago • 
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Studies have shown that vitamin D levels have an inverted U-shaped curve, where low levels (<29.7 nmol/L) result in shortened telomeres on DNA, a sign of aging, but so do high levels of vitamin D (>95.9 nmol/L). Population-based studies and randomized clinical trials have shown a U- or J-shaped curve and suggested an increased risk of adverse outcomes in those with the highest serum Vitamin D levels, including falls, fractures, and frailty. Most studies have reported a higher risk in those participants with serum levels above 100 nmol/L. Are the deleterious effects noted in these studies caused by elevated vitamin D? If so, your support for taking 5,000 to 10,000 IU of vitamin D3 daily seems risky. What is most important for us to know?
ClosedNicola asked 8 hours ago • 
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Worldwide, the incidence of cancer in people younger than 50 rose by 79% and cancer-related deaths rose by 28%, from 1990 to 2019 as reported in the medical journal BMJ Oncology. The numbers are increasing for 17 types of cancer, so this is a broad trend. Why is this happening, despite public awareness of health risks and increased vigilance?
ClosedNicola asked 7 months ago • 
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A recent analysis in the June JAMA Network Open, by Philip Rosenberg and Adalberto Miranda-Filho at the National Cancer Institute, of data from 3.8 million people diagnosed with invasive cancers showed a generational worsening underway. Generation X women, compared to baby boomers, have projected increases by age 60 in thyroid, kidney, rectal, uterine, colon, pancreatic, and ovarian cancers, as well as leukemia and non-Hodgkin’s lymphoma. There were forecasted rises in Gen-X men for thyroid, kidney, rectal, colon, and prostate cancers. The authors note some of the increase may be due to better screening, but attribute many of the increased cancers to risks of lifestyle factors like obesity, diet, and lack of exercise. What is Creator’s perspective?
ClosedNicola asked 1 year ago • 
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