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A number of research studies have been called into question because of poor reproducibility when an attempt to replicate their findings failed. A “replication crisis” has been noted for psychology, sociology, education, economics, and medical research. For example, a detailed inquiry was mounted to replicate 193 experiments from 53 top cancer papers published from 2010-2012. Only a quarter of the original findings were able to be reproduced. Moreover, even for effects that were reproduced, the magnitude averaged 85% less than observed in the original investigations. This is concerning because such experiments are crucial for deciding what to pursue for drug development and when to proceed to clinical trials. Unreliable results not only waste money but expose patients to unnecessary risks. While there are many understandable reasons why results can vary, what can Creator tell us about hidden reasons for such poor reproducibility and their impact on the reliability of scientific inquiry?
ClosedNicola asked 14 hours ago • 
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