DWQA Questions › Tag: randomized clinical trialsFilter:AllOpenResolvedClosedUnansweredSort byViewsAnswersVotesThe Pfizer and Moderna COVID-19 vaccines did not impact overall mortality, a reanalysis of clinical trial data found. The two vaccines, both based on messenger RNA (mRNA) technology, protected against deaths from COVID-19 but that effect was offset by vaccinated trial participants being more likely to die from cardiovascular problems, Christine Stabell Benn, a health professor at the University of Southern Denmark, and other researchers reported in April in the journal, Cell. On the other hand, vaccines that utilized adenoviruses, such as the Johnson & Johnson vaccine, had a favorable impact on both COVID-19 mortality and overall mortality, according to the reanalysis. The research analyzed data from randomized clinical trials (RCTs) reported by the companies that manufacture the vaccines. “In the RCTs with the longest possible blinded follow-up, mRNA vaccines had no effect on overall mortality despite protecting against some COVID-19 deaths. On the other hand, the adenovirus-vector vaccines were associated with lower overall mortality,” researchers said. Is this re-analysis accurate and trustworthy? What is the conclusion we should draw from this work?ClosedNicola asked 11 months ago • Coronavirus COVID-19254 views0 answers0 votes