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A viewer asks: “Being aware of Creator’s previous answers on Vitamin D3 supplementation I was shocked to discover a paper from 2014 “A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D”. The paper claims that the Recommended Daily Allowance advocated by the Institute of Medicine for Vitamin D was incorrectly calculated! In fact, analyzing the data correctly, nearly 9000 IUs per day are required to achieve target levels (600 IU per day is the USA recommended level). I was struck by how closely the 9000 IU figure matched Creator’s “daily doses of 5,000 to 10,000 IU vitamin D3 will rarely be harmful.” What is Creator’s perspective on this “miscalculation” coming to light?”
ClosedNicola asked 1 month ago • 
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A British group reported recently that administration of vitamin D2, which is converted to vitamin D3 by the body, may be disadvantageous. A review of random controlled trials showed that taking vitamin D2 can lead to a decrease in vitamin D3 levels, the more active form generated by sunlight exposure. The research indicates that D2 supplementation may not only be less effective, but can also lead to lower concentrations of D3 in the circulation. [Emily I G Brown, et al. Effect of Vitamin D2 Supplementation on 25-Hydroxyvitamin D3 Status: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutr Rev, 2025 Sep 18:nuaf166.doi: 10.1093/nutrit/nuaf166]. Is this an accurate and meaningful assessment? What is most important for us to know?
ClosedNicola asked 1 month ago • 
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A review article shows little or no benefit of supplementing patients with vitamin D3 for bone fractures (T. Gatt, A. Grech, and H. Arshad. The effect of Vitamin D supplementation for bone healing in fracture patients: a systematic review. Adv. Orthopedics Volume 2023, Article ID 6236045). However, the supplement doses of vitamin D3 were either low, 800-2000 IU daily, or quite high loading doses orally or systemically of 100,000 to 300,000 IU. Was their negative assessment justified or were the studies flawed? Would taking a 5000 to 10,000 IU dose of vitamin D3 daily, give significant benefit for healing bone fractures?
ClosedNicola asked 3 months ago • 
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I have been using a 125 mg ashwagandha supplement from Life Extension as the major source of this nutraceutical. It costs $7.50 for 60 doses. The more recent introduction of Amazing Ashwa from Force Factor has 1400 mg Ashwagandha (800 mg Ashwagandha root powder and 600 mg KSM-66 Ashwagandha root extract) plus extracts with 200 mg Ginseng, 150 mg Goji berry, 100 mg Bacopa monnieri, 100 mg Green Tea, 100 mg Black Maca, 100 mg Rhodiola rosea, and including 100 mg L-Theanine, 40 mcg (1600 IU) Vitamin D, 10 mg Niacin, 2 mg Vitamin B6, 25 mcg Vitamin B12, 192 mg Calcium and 149 mg Phosphorus as Dicalcium Phosphate, 15 mg Zinc Oxide, 50 mcg Selenium (L-Slelenomethionine) and 5 mg BioPerine Black pepper fruit extract. The supplement costs $15.00 for 30 doses of four tablets. Is the Amazing Ashwa supplement significantly more beneficial than taking just 125 mg ashwagandha from Life Extension?
ClosedNicola asked 3 months ago • 
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Given the much higher levels of Ashwagandha in the Amazing Ashwa supplement, could there be sufficient benefit for most users or myself from taking just two of the tablets per dose? That would double the length of coverage with each bottle, and halve the purchase price. It would also halve the dose delivered of all the other ingredients.
ClosedNicola asked 3 months ago • 
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NaturaLife Labs offers a supplement with 2100 mg Ashwagandha alone, as a blend of root powder and root extract, along with black pepper to improve bioavailability. At 3 tablets per dose, one bottle could cover three months taking just a single 700 mg tablet, for about the same cost as Amazing Ashwa. Is the 2100 mg dose of Ashwagandha in the NaturaLife Labs product overkill, or would that high a dose give a significantly greater benefit?
ClosedNicola asked 3 months ago • 
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Many Red Light Therapy devices only deliver visible red and near-infrared wavelengths. How significant for healing is exposure to far-infrared wavelengths?
ClosedNicola asked 3 months ago • 
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A systematic review of 416 medical journal articles affirmed a strong association between higher serum vitamin D levels and a lower risk of bladder, breast, colon, endometrial, esophageal, gallbladder, kidney, ovarian, pancreatic, rectal, stomach, and vulvar cancers, as well as Hodgkin’s and non-Hodgkin’s lymphomas. The review also uncovered lower risks of metastasis and mortality from cancer in patients with higher levels of vitamin D. While vitamin D levels of 20 ng/ml (50 nmol/L) were adequate for bone and muscle health, reduction of cancer risk and mortality required levels greater than 40 ng/ml (100 nmol/L) and fell further with levels above 50 ng/ml (125 nmol/L). The review cautioned that studies showing no benefit for those taking less than 5,000 IU per day might be misleading. [Wimalawansa SJ. Vitamin D’s impact on cancer incidence and mortality: a systematic review. Nutrients. 2025 Jul 16;17(14):2333. Doi: 10.3390/nu17142333.] Is this a fair summary of vitamin D benefits for limiting incidence and severity of cancer?
ClosedNicola asked 3 months ago • 
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You have told us that 5000 IU of vitamin D3 taken twice a day would be safe and helpful for many, many people. Is that enough to get serum levels in a useful range for cancer prevention?
ClosedNicola asked 3 months ago • 
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Studies have shown that vitamin D levels have an inverted U-shaped curve, where low levels (<29.7 nmol/L) result in shortened telomeres on DNA, a sign of aging, but so do high levels of vitamin D (>95.9 nmol/L). Population-based studies and randomized clinical trials have shown a U- or J-shaped curve and suggested an increased risk of adverse outcomes in those with the highest serum Vitamin D levels, including falls, fractures, and frailty. Most studies have reported a higher risk in those participants with serum levels above 100 nmol/L. Are the deleterious effects noted in these studies caused by elevated vitamin D? If so, your support for taking 5,000 to 10,000 IU of vitamin D3 daily seems risky. What is most important for us to know?
ClosedNicola asked 3 months ago • 
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A viewer asks: “What can you tell us about the benefits versus risk factors in taking the bone medication Evenity? Cost is high, but insurance can help. Can you tell us if it is highest and best to take this or if it would be better to continue LHP-DSMR healing requests without outside chemical interventions? Side effects with this drug are concerning.”
ClosedNicola asked 3 months ago • 
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Am I taking too much vitamin D3? Dr. Sears recommends 2000 IU daily. I am taking two 5000 IU gelcaps. Is it better to take half at noon and half at night, or is taking two together wasteful?
ClosedNicola asked 6 months ago • 
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Is the vitamin D3 I am taking going to waste unless I take a more absorbable form of zinc, like zinc acetate?
ClosedNicola asked 6 months ago • 
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A viewer asks: “Seasilver was a supplement containing the herb pau d’arco, cranberry, and aloe. It got a lot of fanfare back in the late 90s and early 2000s. It was run out of business by the FTC and fined $120 million. They ceased doing business in 2006. Was this an ‘honest’ product being sold for its genuine health benefits? Or a scam? Or was it a good product whose benefits were exaggerated intentionally, with awareness, or unintentionally? Did they legitimately run afoul of the FDA and FTC, or were they targeted by overzealous enforcement, reading ‘too much’ into the laws and regulations governing supplements? Who are the bad guys here and who are the good guys, or were they both breaking and bending the rules of ‘fair play?'” What can Creator tell us?
ClosedNicola asked 1 year ago • 
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He asks: “Did this constitute an interloper backlash of the manufacturers and sellers of this Seasilver product? Is this an object lesson we should be mindful of?” What can Creator tell us?
ClosedNicola asked 1 year ago • 
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