DWQA Questions › Tag: clinical trialsFilter:AllOpenResolvedClosedUnansweredSort byViewsAnswersVotesA number of research studies have been called into question because of poor reproducibility when an attempt to replicate their findings failed. A “replication crisis” has been noted for psychology, sociology, education, economics, and medical research. For example, a detailed inquiry was mounted to replicate 193 experiments from 53 top cancer papers published from 2010-2012. Only a quarter of the original findings were able to be reproduced. Moreover, even for effects that were reproduced, the magnitude averaged 85% less than observed in the original investigations. This is concerning because such experiments are crucial for deciding what to pursue for drug development and when to proceed to clinical trials. Unreliable results not only waste money but expose patients to unnecessary risks. While there are many understandable reasons why results can vary, what can Creator tell us about hidden reasons for such poor reproducibility and their impact on the reliability of scientific inquiry?ClosedNicola asked 5 days ago • Extraterrestrial Corruption of Human Institutions22 views0 answers0 votesA $100 million clinical study (ISCHEMIA) followed more than 5,000 men and women from 37 countries with severe but stable heart disease to assess the value of procedures to help their coronary artery disease. Was the ISCHEMIA clinical trial compromised by the interlopers to discourage use of stents and coronary bypass procedures?ClosedNicola asked 3 years ago • Extraterrestrial Corruption of Human Institutions357 views0 answers0 votesThere have been prominent announcements from the FDA about the inadvisability and dangers of people using ivermectin to treat COVID-19. Caution about taking pill formulations intended for large animals by humans is understandable, but this seems to have the same feel as the trashing of hydroxychloroquine early and often by the medical establishment exaggeration of possible side effects and even alteration of the data in clinical trials to make it falsely look both ineffective and highly toxic. Is that planned or underway to deliberately undercut further studies of ivermectin?ClosedNicola asked 4 years ago • Coronavirus COVID-19451 views0 answers0 votesWill further clinical studies of fluvoxamine in patients with COVID-19 be suppressed by the US medical establishment as they have done for hydroxychloroquine?ClosedNicola asked 4 years ago • Coronavirus COVID-19418 views0 answers0 votesIn a preliminary study of adult outpatients with symptomatic COVID-19, patients treated with fluvoxamine, compared with placebo, had a lower likelihood of clinical deterioration. There was clinical deterioration in 0 of 80 patients in the fluvoxamine group and in 6 of 72 patients in the placebo group (absolute difference, 8.7% [95% CI, 1.8%-16.4%] from survival analysis; log-rank P = .009). The fluvoxamine group had 1 serious adverse event and 11 other adverse events, whereas the placebo group had 6 serious adverse events and 12 other adverse events. Is this a worthwhile agent for COVID-19 management? How would it compare with hydroxychloroquine or ivermectin?ClosedNicola asked 4 years ago • Coronavirus COVID-19448 views0 answers0 votesAn osteopathic physician and frequent spokesperson on the Internet says there are at least 10 ways that the SARS-CoV-2 mRNA vaccines can cause serious side effects in human recipients. Is this the case, or an exaggeration? Why is she beating this drum?ClosedNicola asked 4 years ago • Coronavirus COVID-19665 views0 answers0 votesIs there a danger that clinical trials of COVID-19 vaccines will be interfered with by the Extraterrestrial Alliance to show lack of effectiveness, even if the approach can work?ClosedNicola asked 5 years ago • Coronavirus COVID-19423 views0 answers0 votesIs there a likelihood the Extraterrestrial Alliance will rig a vaccine trial to falsely show effectiveness, so it will be embraced by the masses, but useless, except to deliver locater chips?ClosedNicola asked 5 years ago • Coronavirus COVID-19458 views0 answers0 votesIs the information on chlorine dioxide effectiveness for curing malaria accurate, that it was 100% effective, as described by Dr. Andreas Ludwig Kalcker?ClosedNicola asked 5 years ago • Coronavirus COVID-19507 views0 answers0 votesA study just completed in the U.S. and Canada of 821 health care workers exposed to people with COVID-19 infections failed to show a statistically significant benefit of hydroxychloroquine in preventing infections (11.8% with hydroxychloroquine versus 14.3% of placebo group became ill). There was also no significant lessening of disease severity once they became symptomatic. How can the data be explained in view of your support for hydroxychloroquine use?ClosedNicola asked 5 years ago • Coronavirus COVID-19407 views0 answers0 votesThe New England Journal of Medicine just published a non-randomized study of hydroxychloroquine coupled with azithromycin in patients with moderate to severe COVID-19 infections, showing no benefit compared to a control group, using intubation or death as endpoints. Can you comment on the prospects for this therapy, in light of this study and your prior endorsement of this treatment?ClosedNicola asked 5 years ago • Coronavirus COVID-19395 views0 answers0 votesIs the recent small study combining azithromycin with hydroxychloroquine in treating coronavirus COVID-19 accurate in reflecting significant clinical benefit due to both anti-inflammatory and antiviral replication activities? Will this be a valuable adjunct in reducing the impact of the pandemic?ClosedNicola asked 5 years ago • Coronavirus COVID-19534 views0 answers0 votes