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A new review in the Annals of Internal Medicine (August 26, 2025) of 99 studies including over 221,000 participants from 15 countries, found that using cannabis products with high levels of THC is linked with increased risk for psychosis or schizophrenia, especially within 12 hours after use, as well as risk of addiction. Compared to recreational cannabis sources available in the 1960s through the 1980s containing 2-4% THC, levels have increased to an average of 20% currently. Vaping devices can deliver 70-90% THC. Evidence is lacking for any medicinal benefit of cannabis in treating those with diagnosed psychotic illness and weak at best for helping anxiety or depression in otherwise normal people. In fact, among recreational users, studies showed increases of 53% and 41% in anxiety and depression, respectively. The drive to legalize cannabis across the US has been accelerating. Will that win out, despite the growing incidence of harm to users? What is most important for us to know?14 views0 answers0 votes