Your intuition here is correct, that the scientific studies on berberine are, indeed, meaningful despite the relatively high concentrations needed in vitro to inhibit viral replication. We can work with the level of berberine of this supplement to see it gets to where it is needed to begin dialing back not only the virus but malignant cells that might be generated from such chronic infections. It is not a perfect answer but will be meaningful and of assistance to helping the divine realm work towards eradicating diabetes as one example of afflictions for which people take berberine supplements.
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