Are her lack of motivation, anxiety, and panic attacks caused by spirit meddler attachments or other karmic trauma?

While there are karmic elements being ramped up by her spirit attachments, this combination of emotional difficulties is primarily the result of the ongoing perturbation of the mind and the steady bullying she is receiving within the deep subconscious mind. This is keeping her on high alert much of the time and drains her energy, as well as leading her to a state of depression. People can only take so much without reaching a limit, and then may have a breakdown totally, or have a kind of withdrawal as a kind of resignation, giving in to the overwhelming torment, and this can spill over into conscious awareness of feeling depleted. So this will improve once the spirits are removed and if this clearance is maintained.