Unfortunately, this is the case. As you know, the microbial world with its very rapid generation time, can readily react to environmental pressures and adapt genetically in ways humans cannot because of their much longer timelines and the much wider array of human activities for which the genetics are only a basal, indirectly connected launching pad. The issues surrounding microbial well-being, when it comes to devising therapeutics to counter them, involves a much more restricted set of genetic elements that are designed to interact with the environment already because the microbes live in many environmental niches that require some adaptability and some tolerance for harsh conditions as well, much more so than is the case for human beings. So the ability to launch defensive measures, including some modification of gene expression to counteract a negative stimulus of some kind, is an aspect of their makeup.
Humans are not designed to be naked in the world because they are endowed with intelligence to seek protective means and devise them, so even with that potential, it is inimical to the interests of pathogens to kill their host because they are destroying their own best habitat. It would be much better to live in relative peace and harmony as a symbiont rather than a lethal attacker. This is what has been enhanced through time by the interlopers to take organisms that are invasive, and have this capability already, and to greatly enhance their virulence, and also to make modifications to impart antibiotic resistance in response to human efforts to devise effective treatment strategies. This is a kind of game they play so they can watch humans take one step forward and then two steps back as the rug is pulled out from under them by the Extraterrestrial Alliance.