The Manuka honeys having higher MGO (methylglyoxal) content are higher in cost. Can you help us understand when that might be worth using?

We would say that when the stakes are high, due to an ongoing medical condition of significance, that is when getting the best possible adjunct is worth the time and money to arrange. So someone with a long-term failure for a wound to heal or who is in a compromised position due to impairment of their immune system, to have something that will provide prophylactic benefit can prevent serious and even fatal long-term outcomes.