Will sudden disappearance of large numbers of humans be an early warning of an impending launch of the annihilation?

This may become noticed depending on how it is carried out in a time sense. They can get away with many things by staging it bit by bit. They are able to cover up many mass events totally through mind control manipulation, so there is no guarantee that this would be an early warning that is clearly recognized and reported widely in the media. That is yet another uncertainty, that many unusual events are simply ignored by editors due to mind manipulation to discount them and see them as not of interest to the viewership. And, of course, this is a manipulation and a form of secret-keeping subterfuge and disinformation, but it is done all the time and is highly effective in shaping the human culture, keeping many secrets buried, and hiding much of reality from scrutiny by human beings, some of whom are still awake enough to see something is amiss. But there will be many things going wrong with a general worsening across the board with so many different sources of stress and liability, with breakdown of institutions, increased natural disasters, and mistakes and missteps by the governing bodies charged with maintaining order and keeping people safe and supported. So it will be the aggregate of the worsening that will be a clear prelude to the annihilation itself. Keep in mind this will be gradual and over a period of years, as it has already commenced and has been unfolding for years already. So this is subjective, but you can get a sense of the trajectory of things by looking at the big picture and kind of taking the temperature of how things are heating up, and that will be a rough guide and predictor of whether things are still moving towards that dark eventuality or might be moderating if there is a slowdown of new catastrophes and a moderation of disruptions. That will only happen with a significant divine intervention as a result of enough human participation to bring it about. This is what is needed and why we need everyone sounding the alarm and spreading the word and encouraging fellow humans to do prayer and healing work for the perpetrators and humanity as a whole.