To be most comprehensive, the first three would be useful in combination. They will not be equally essential for everyone, but the difficulty is in knowing enough about individual ingredients with respect to the diagnostic vagaries in truly categorizing vision problems and issues and how they come about. It is also the case that what might be needed at the moment is just the beginning of a series of problems that may worsen over time or grow in number, with somewhat differing needs and new issues arising because of karmic milestones, for example. It is easier to prevent problems in using such nutraceuticals as prophylactic care than as a rescue strategy once severe impairment has taken place. We would say better late than never, but it is also strategic to get ahead and stay ahead of potential problems by doing everything you can to support the normal function of key organs and tissues in the body.
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